Hydroxypropyl methylcellulose (HPMC) waa polymer la taaban karo oo si ballaaran loo isticmaalo warshado kala duwan, oo loo yaqaan sifooyinkeeda gaarka ah iyo codsiyada.Xaruntani waa unug ka soo jeeda cellulose, polymer-ka dabiiciga ah ee laga helo gidaarada unugyada dhirta.Si loo fahmo ka kooban hydroxypropylmethylcellulose, waxaa lagama maarmaan ah in la dhex geliyo qaab-dhismeedka iyo synthesize this derivative cellulose.
Qaab dhismeedka cellulose:
Cellulose waa karbohaydrayt kakan oo ka kooban silsilad toosan oo ah unugyo gulukoos β-D-ku xidhan β-1,4-glycosidic bonds.Silsiladahan gulukoosta waxaa isku haya curaarta hydrogen si ay u sameeyaan qaab-dhismeed toosan oo adag.Cellulose waa qaybta ugu muhiimsan ee dhismaha derbiyada unugyada dhirta, taasoo siisa xoog iyo qallafsanaan unugyada dhirta.
Waxyaabaha laga soo saaro Hydroxypropyl Methylcellulose:
Hydroxypropyl methylcellulose waxaa lagu farsameeyay iyadoo kiimiko ahaan wax looga beddelayo cellulose iyo soo bandhigida hydroxypropyl iyo kooxaha methyl silsiladda ugu weyn ee cellulose.Wax soo saarku inta badan waxa ku jira talaabooyinkan soo socda:
Dareen-celinta Etherification:
Methylation: Daweynta cellulose leh xal alkaline ah iyo methyl chloride si loo soo bandhigo kooxaha methyl (-CH3) kooxaha hydroxyl (-OH) ee cellulose.
Hydroxypropylation: Methylated cellulose waxay si dheeraad ah uga falcelisaa propylene oxide si ay u soo bandhigto kooxaha hydroxypropyl (-CH2CHOHCH3) qaabdhismeedka cellulose.Habkani wuxuu wanaajiyaa milanka biyaha wuxuuna beddelaa sifooyinka jireed ee cellulose.
nadiifinta:
Cellulose-ka wax laga beddelay ayaa markaa la nadiifiyaa si looga saaro wax kasta oo reagen ah, alaab-soo-saar ama wasakh.
Qalajinta iyo shiididda:
Hydroxypropyl methylcellulose ee la safeeyey waa la qalajiyey oo lagu rusheeyey budo ganaax ah oo diyaar u ah in loo isticmaalo codsiyo kala duwan.
Waxyaabaha ay ka kooban tahay Hydroxypropyl Methylcellulose:
Halabuurka hydroxypropyl methylcellulose waxaa lagu gartaa heerka beddelka, taas oo loola jeedo heerka ay hydroxypropyl iyo methyl kooxaha bedelayaan kooxaha hydroxyl ee silsiladda cellulose.Heerarka kala duwan ee HPMC waxay leeyihiin heerar kala duwan oo beddelaad ah, taas oo saamaynaysa milmayntooda, viscosity-kooda iyo guryaha kale.
Qaabka kiimikaad ee hydroxypropyl methylcellulose waxa lagu tilmaami karaa sida (C6H7O2(OH)3-mn(OCH3)m(OCH2CH(OH)CH3)n)_x, halka m iyo n ay matalaan heerka badalka.
m: heerka methylation (kooxaha methyl halkii unug gulukoos)
n: heerka hydroxypropylation (kooxaha hydroxypropyl unugga gulukoosta)
x: tirada unugyada gulukooska ee silsiladda cellulose
Astaamaha iyo Codsiyada:
Solubility: HPMC waa biyo-milmi kara, iyo heerka beddelka ayaa saameeya sifooyinkiisa milmay.Waxay samaysaa xal cad oo viscous ah biyaha, taas oo ka dhigaysa mid ku habboon noocyo kala duwan oo qaabab ah.
Viscosity: Neefsashada xalka HPMC waxay kuxirantahay arrimo ay ka mid yihiin miisaanka kelli iyo heerka beddelka.Hantidani waxay muhiim u tahay codsiyada sida dawooyinka u baahan qaabaynta la xakameeyey.
Sameynta Filimka: HPMC waxay sameyn kartaa filimo khafiif ah marka uu xalku engego, taasoo ka dhigaysa mid faa'iido u leh dahaarka dawooyinka, cuntada iyo warshadaha kale.
Xasijiyeyaasha iyo dhumucyada: Warshadaha cuntada, HPMC waxa loo isticmaalaa dhumuc iyo xasiliye ahaan badeecooyin kala duwan, oo ay ku jiraan suugo, macmacaanka, iyo alaabta la dubay.
Codsiyada Dawada: HPMC waxaa si weyn loogu isticmaalaa qaababka dawooyinka, oo ay ku jiraan kiniiniyada, kaabsalka, iyo xalalka indhaha, iyadoo ay ugu wacan tahay sifooyinkeeda la kontoroolo iyo isqabqabsiga noole.
Dhismaha iyo dahaarka: HPMC waxa loo isticmaalaa agabka dhismaha sida hoobiyeyaal, xabagta tile-ka iyo balastarrada.Waxa kale oo loo isticmaalaa sidii dhumuc iyo xasiliye ahaan rinji iyo qaabaynta dahaarka.
Alaabooyinka Daryeelka Shakhsi ahaaneed: Warshadaha isqurxinta iyo daryeelka shakhsi ahaaneed, HPMC waxaa laga helaa alaabada sida kiriimyada, looshannada iyo shaambooyinka, halkaas oo ay ku siiso qaab-dhismeed iyo xasilooni.
Hydroxypropyl methylcellulose waxaa lagu helaa methylation iyo hydroxypropylation of cellulose.Waa polymer ujeedo badan leh oo leh adeegsi badan.Hantideeda gaarka ah waxay ka dhigtaa mid qiimo leh warshadaha sida dawooyinka, cuntada, dhismaha iyo daryeelka shakhsi ahaaneed.Beddelka la xakameeyey ee cellulose wuxuu hagaajin karaa sifooyinka HPMC, taasoo ka dhigaysa qayb muhiim ah oo ka mid ah alaabooyin badan oo aan la kulanno nolol maalmeedkeena.
Waqtiga boostada: Jan-10-2024