Hydroxypropyl methyl cellulose HPMC waa unug aan-ionic cellulose isku qasan in noocyo kala duwan iyo ionic methyl carboxymethyl cellulose ether qasan, waxa aanu ka falcelin la biraha culus.Mid ka mid ah xagjirnimada oksijiinta sababta oo ah hydroxypropyl methyl cellulose content iyo saamiga kala duwan ee content hydroxypropyl iyo viscosity, noqday noocyo kala duwan oo ku saabsan waxqabadka, tusaale ahaan, content methoxyl sare iyo content hoose ee noocyada hydroxypropyl, waxqabadkeedu wuxuu ku dhow yahay cellulose methyl iyo methoxyl hooseeya. content iyo content sare ee noocyada hydroxypropyl, iyo waxa ay waxqabad ku dhow yahay hydroxypropyl methyl cellulose la soo saaray.Laakiin nooc kasta, inkasta oo kaliya ay ku jiraan qadar yar oo hydroxypropyl ah ama qadar yar oo methoxy ah, milanka dareeraha organic ama heerkulka flocculation ee xalka aqueous, waxaa jira farqi weyn.
1, hydroxypropyl methyl cellulose solubility
Hydroxypropyl methyl cellulose ee milanka biyaha ee hydroxypropyl methyl cellulose dhab ahaantii waa nooc ka mid ah propylene oxide (methyl oxypropyl giraanta) methyl cellulose wax laga beddelay, sidaas darteed waxa ay weli la mid tahay methyl cellulose biyo qabow oo milmay iyo sifooyin biyo kulul aan la milmi karin.Si kastaba ha ahaatee, heerkulka gelation ee hydroxy propyl la beddelay ayaa aad uga sarreeya kan methyl cellulose ee biyaha kulul.Tusaale ahaan, viscosity of hydroxypropyl methylcellulose xal aqueous leh 2% methoxy content DS=0.73 iyo hydroxypropyl content MS=0.46 waa 500mpa at 20℃.Heerkulka jel ee badeecada S wuxuu ku dhow yahay 100 ℃, halka kan methyl cellulose ee isla heerkulka uu yahay kaliya 55℃.Sida milanka biyaha, sidoo kale si weyn ayaa loo hagaajiyay, tusaale ahaan, ka dib markii la burburiyo hydroxypropyl methylcellulose (qaabka hadhuudhka 0.2 ~ 0.5mm at 20℃ 4% viscosity aqueous of 2pA? S alaabta si fudud u milmi karaa biyaha iyada oo aan qaboojin heerkulka qolka. .
(2) Hydroxypropyl methyl cellulose ee dareerayaasha organic milanka ee hydroxypropyl methyl cellulose ee dareeraha organic, sidoo kale waa ka fiican yahay methyl cellulose, baahida methyl cellulose ee heerka beddelka methoxy ee 2.1 ama wax ka badan, oo ka kooban hydroxypropyl MS=1.5 ~ 1.8 iyo methoxypropyl. DS=0.2~1.0.Waxa kale oo ay ku milmi kartaa hydrocarbons koloriin leh sida dichloromethane iyo trichloromethane, iyo dareerayaasha organic sida acetone, khamriga isopropyl, iyo aalkolada diacetone.Ku milmaynteeda dareerayaasha organic ayaa ka sarreeya milanka biyaha.
2, hydroxypropyl methyl cellulose viscosity ee arrimaha saamaynta leh
Hydroxypropyl methylcellulose viscosity factors hydroxypropyl methylcellulose heerka viscosity go'aaminta, iyo ether kale cellulose waa isku mid, waa 20℃ oo leh 2% xal aqueous sida go'aaminta caadiga ah.Viscosity ee badeecada isku midka ah, oo leh kororka feejignaanta iyo korodhka, isku-darka isku midka ah ee alaabta miisaanka kelliyada ee kala duwan, miisaanka kelli ee alaabta ayaa ah viscosity sare.Xidhiidhka ay la leedahay heerkulka ayaa la mid ah kan methyl cellulose.Marka heerkulku kor u kaco, viscosity-ku wuxuu bilaabmaa inuu hoos u dhaco, laakiin marka uu gaaro heerkul gaar ah, viscosity-ku si lama filaan ah ayuu kor ugu kacaa oo dhalaalku wuu yimaadaa.Heerkulka gelation-ka ee alaabooyinka leh mawqifkoodu hooseeyo ayaa ka sarreeya kan alaabooyinka leh aragti sare.Heerka dhibicdeeda gel, marka lagu daro viscosity sare iyo hoose ee ether, laakiin sidoo kale leh ether methoxy iyo hydroxypropyl saamiga kooxda iyo wadarta heerka beddelka ayaa la xidhiidha.Waa in la ogaadaa in hydroxypropyl methylcellulose sidoo kale waa pseudoplastic;xalkeedu wuu xasiloon yahay marka lagu kaydiyo heerkulka qolka mana muujinayo wax hoos u dhac ku ah viscosity marka laga reebo suurtagalnimada xaalufka enzymatic.
3, hydroxypropyl methyl cellulose acid iyo caabbinta alkaline
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid iyo alkali, guud ahaan waa xasiloon, ee ph PH2 ~ 12 kala duwan ma saameyn, waxay u adkeysan kartaa qadar gaar ah oo acid iftiin ah, sida formic acid, acetic acid, citric acid, succinic acid, phosphoric aashitada, boric acid, iwm. Laakiin aashitada xoogga leh waxay leedahay saamaynta yaraynta viscosity-ka.Alkali sida soodhaha caustic, potassium caustic iyo biyaha lime wax saameyn ah kuma laha, laakiin saameynta wax yar kordhinta viscosity ee xalka ayaa si tartiib tartiib ah u yaraan doona mustaqbalka.
4, hydroxypropyl methyl cellulose waa la isku dari karaa
Xalka hydroxypropyl methyl cellulose waxaa lagu qasi karaa xeryahooda polymer-ka biyaha-milmi kara, waxayna noqdaan xal isku mid ah oo hufan oo leh viscosity sare.Xeryahooda molecular sare waa polyetylen glycol, polyvinyl acetate, polysilicon, polymethyl vinyl siloxane iyo hydroxyethyl cellulose iyo methyl cellulose, iwm. xal.Hydroxypropyl methyl cellulose sidoo kale waxaa lagu qasi karaa stearic acid ama palmitic acid mannitol ester ama sorbitol ester, laakiin sidoo kale leh glycerol, sorbitol iyo mannitol, xeryahooda waxaa loo isticmaali karaa sida hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose biyo aan milmi karin
Hydroxypropyl methyl cellulose eter-ka cellulose-ka ee aan milmi karin, waxay noqon kartaa iskutallaabta dusha sare leh aldehydes, oo waxay ka dhigi kartaa eter-ka biyaha-milmi kara ee xalinta, waxay noqdaan kuwo aan milmi karin biyaha.Oo samee hydroxypropyl methylcellulose aldehyde aan la karin karin, formaldehyde, glyoxal, succinaldehyde, dialdehyde, iwm., isticmaalka formaldehyde waa in fiiro gaar ah u leh qiimaha PH ee xalka, taas oo falcelinta glioxal si dhakhso ah, sidaas darteed wax soo saarka warshadaha sida caadiga ah loo isticmaalo glioxal sida iskutallaabta. -wakiil isku xira.Qiyaasta wakiilka noocan oo kale ah ee isku dhafka ah ee xalka waa 0.2% ~ 10% miisaanka ether, ugu fiican waa 7% ~ 10%, sida isticmaalka glioxal oo leh 3.3% ~ 6% waa tan ugu habboon.Heerkulka daawaynta guud waa 0 ~ 30℃, waqtiguna waa 1 ~ 120min.Dareen-celinta isku-xiran waxay u baahan tahay in lagu sameeyo xaaladaha acidic.Guud ahaan, aashitada xoogga leh ee aan organic ama karboksylic acid organic ayaa lagu daraa xalka si loo hagaajiyo PH ee xalka ilaa 2 ~ 6, oo la doorbidayo inta u dhaxaysa 4 ~ 6, ka dibna aldehydes ayaa lagu daraa falcelinta isku-xiran.Asiidhyada la isticmaalo waa hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid ama citric acid, kuwaas oo ay ka mid yihiin formic acid ama acetic acid ayaa ugu fiican, halka formic acid uu yahay kan ugu fiican.Acids iyo aldehydes ayaa sidoo kale lagu dari karaa isla waqti isku mid ah si loogu oggolaado xalka in la isku xiro inta la rabo PH.Dareen-celintan waxaa inta badan loo isticmaalaa habka ugu dambeeya ee habka diyaarinta ether cellulose, si ether cellulose uusan milmin, fududahay in la isticmaalo 20 ~ 25 ℃ biyo si loo dhaqo oo loo nadiifiyo.Marka badeecada la isticmaalo, walxaha alkaline ayaa lagu dari karaa xalka alaabta si loo hagaajiyo PH ee xalka si uu u noqdo alkaline, badeecaduna si dhakhso ah ayaa loogu milmaa xalka.Habkani waxa kale oo loo isticmaali karaa marka cellulose ether xal loo isticmaalo si loo sameeyo filim ka dibna filimka waxaa lagu daaweeyaa si loo sameeyo filim aan la milmin.
6, hydroxypropyl methyl cellulose anti-enzyme
Hydroxypropyl methyl cellulose enzyme iska caabin ah oo ka mid ah unugyada cellulose in theory, sida kooxaha anhydroglucose kasta sida ay jiraan isku darka adag ee beddelka kooxaha, nabaad guurka ee microorganisms waa yar u nugul infekshanka, laakiin dhab ahaantii alaabta la dhammeeyey si ay u beddelaan qiimaha ka badan 1, Sidoo kale hoos u dhigista enzyme, tani waa sharaxaadda koox kasta oo ku jirta darajada beddelka silsiladda cellulose ma aha mid la mid ah, Microorganisms waxay baabi'in karaan kooxaha gulukooska fuuqbaxa ee aan la bedelin si ay u sameeyaan sonkor, taas oo ay nuugi karto microorganisms cunto ahaan.Sidaa darteed, haddii heerka beddelka etherification ee cellulose uu kordho, iska caabinta ether-ka cellulose-ka ee nabaad-guurka enzymatic ayaa la wanaajin doonaa.Waxaa lagu soo waramayaa in xaaladaha la xakameeyey, viscosity haraaga ee hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), iyo hydroxyethyl cellulose (1.7%) ahaa 13.2%, 7.3% 3.8%, iyo 1.7%, siday u kala horreeyaan.Hydroxypropyl methyl cellulose waxay leedahay awood xoog leh oo anti-enzyme ah.Sidaa darteed hydroxypropyl methylcellulose anti-enzyme aad u fiican, oo ay weheliso kala firdhisanaanteeda wanaagsan, dhumucdeeda iyo samaynta filimka, ayaa lagu dabaqay daahan emulsion, iwm, guud ahaan uma baahna inay ku darto walxaha ilaaliya.Si kastaba ha noqotee, si looga hortago kaydinta muddada dheer ee xalka ama wasakheynta suurtagalka ah ee ka imanaysa dibadda, waxaa lagu dari karaa waxyaabaha lagu keydiyo, kuwaas oo xulashadooda lagu go'aamin karo iyadoo loo eegayo shuruudaha ugu dambeeya ee xalka.Phenylmercuric acetate iyo manganese fluosilicate waa ilaalin wax ku ool ah, laakiin waa sun waana in si taxadar leh loo shaqeeyaa.Guud ahaan, 1 ~ 5mg phenylmercuric acetate ayaa lagu dari karaa litir kasta oo xal ah.
7, hydroxypropyl methyl cellulose xuubka waxqabadka
Waxqabadka filimka hydroxypropyl methyl cellulose ee hydroxypropyl methyl cellulose wuxuu leeyahay filim aad u fiican, xalkeeda aqueous ama xal dareeraha organic, oo lagu daboolay saxanka galaaska, ka dib marka la qalajiyo ayaa noqda mid aan midab lahayn, filim hufan oo adag.Waxay leedahay iska caabin qoyaan oo wanaagsan waxayna ku sii adkaysataa heerkulka sare.Sida ku-darka caagga ah ee hygroscopic, waxay kor u qaadi kartaa dhererkeeda iyo dabacsanaanta, si loo hagaajiyo dabacsanaanta, glycerol iyo sorbitol iyo caagadaha kale ayaa ah kuwa ugu habboon.Xalka guud ee xalku waa 2% ~ 3%, qiyaasta balaastikada waa 10% ~ 20% ether cellulose.Haddii maadada balaastikada ay aad u badan tahay, ifafaalaha yaraanta ee fuuq-baxa kolloid waxay ku dhici kartaa huurka sare.Xoogga jilicsan ee filimka lagu daray balaastiiggu aad ayuu uga weyn yahay kan aan lagu darin, wuxuuna kordhiyaa kororka tirada lagu daray, sida hygroscopicity filimka ayaa sidoo kale la kordhiyaa iyadoo la kordhinayo qadarka balaastiigga.
Waqtiga post: Seb-08-2022