Heerka dawooyinka ee HPMC
Heerka dawooyinka ee HPMCHydroxypropyl methylcellulose waa caddaan ama caano cad, aan ur lahayn, aan dhadhamin, budada fayruuska ah ama granule, lumista miisaanka marka la qalajiyo kama badna 10%, oo lagu milmo biyo qabow laakiin aan ahayn biyo kulul, si tartiib ah biyo kulul Barri, peptization, iyo samaynta xal kolloidal viscous , kaas oo xal noqda marka la qaboojiyo, marka la kululeeyona noqda jel.HPMC waa mid aan lagu milmi karin ethanol, chloroform iyo ether.Waxay ku milmi kartaa dareeraha isku dhafan ee methanol iyo methyl chloride.Waxa kale oo ay ku milmi kartaa dareeraha isku dhafan ee acetone, methyl chloride iyo isopropanol iyo qaar ka mid ah dareerayaasha kale ee dabiiciga ah.Xalka biyaha leh wuxuu u dulqaadan karaa milix (xalkiisa kolloidalka ah ma baabi'iyo milix), iyo pH ee 1% xal aqueous waa 6-8.Qaaciddada molecular ee HPMC waa C8H15O8-( C10H18O6) -C815O, iyo cufnaanta kelliku waxay ku dhowdahay 86,000.
Tilmaamaha Kiimikada
| PHPMC waxyeelada leh Tilmaamid | HPMC60E( 2910) | HPMC65F( 2906) | HPMC75K( 2208) |
| Heerkulka jel (℃) | 58-64 | 62-68 | 70-90 |
| Methoxy (WT%) | 28.0-30.0 | 27.0-30.0 | 19.0-24.0 |
| Hydroxypropoxy (WT%) | 7.0-12.0 | 4.0-7.5 | 4.0-12.0 |
| Viscosity (cps, 2% Xalka) | 3, 5, 6, 15, 50,100, 400,4000, 10000, 40000, 60000,100000,150000,200000 | ||
Heerka Alaabta:
| PHPMC waxyeelada leh Tilmaamid | HPMC60E( 2910) | HPMC65F( 2906) | HPMC75K( 2208) |
| Heerkulka jel (℃) | 58-64 | 62-68 | 70-90 |
| Methoxy (WT%) | 28.0-30.0 | 27.0-30.0 | 19.0-24.0 |
| Hydroxypropoxy (WT%) | 7.0-12.0 | 4.0-7.5 | 4.0-12.0 |
| Viscosity (cps, 2% Xalka) | 3, 5, 6, 15, 50,100, 400,4000, 10000, 40000, 60000,100000,150000,200000 | ||
Codsiga
| FarmaajoExcipientsCodsiga | Pharmadhinaca GHPMC | Qiyaasta |
| Bulk Laxative | 75K4000,75K100000 | 3-30% |
| Kareemada, jel | 60E4000,75K4000 | 1-5% |
| Diyaarinta Indhaha | 60E4000 | 01.-0.5% |
| Diyaarinta Dhibcaha Indhaha | 60E4000 | 0.1-0.5% |
| Wakiilka Joojinta | 60E4000, 75K4000 | 1-2% |
| Antacids | 60E4000, 75K4000 | 1-2% |
| Kiniinnada Binder | 60E5,60E15 | 0.5-5% |
| Convention Qoyan Granulation | 60E5,60E15 | 2-6% |
| Dahaarka kiniinka | 60E5,60E15 | 0.5-5% |
| Matrix siidaynta la xakameeyey | 75K100000,75K15000 | 20-55% |
Tilmaamaha iyo Faa'iidooyinka:
HPMC waxay leedahay milmi biyo aad u fiican oo biyo qabow ah.Waxaa lagu milmi karaa xal hufan oo wax yar ku walaaqaya biyo qabow.Taa lidkeeda, asal ahaan waa lagu milmi karin biyaha kulul ee ka sarreeya 60℃oo kaliya barari kara.Waa eter cellulose aan ionic ahayn.Xalkeedu ma laha lacag ionic ah, ma la falgaliso cusbada birta ah ama xeryahooda organic ionic, kamana falcelinayso alaabta kale ee cayriin inta lagu jiro habka diyaarinta;waxay leedahay dareen diidmo oo xoog leh, iyo marka heerka beddelka ee qaab-dhismeedka molecular uu kordho, way u adkaysataa xasaasiyadda oo aad u xasilloon;sidoo kale waa dheef-shiid kiimikaad.Ka-faa'iideyste farmashiyeed ahaan, lama dheefsado ama la nuugo.Sidaa darteed, ma bixiso kulaylka daawooyinka iyo cuntooyinka.Waa kaloori-yar, milix-la'aan, iyo milix-la'aan dadka sokorowga qaba.Daawooyinka xasaasiyadda iyo cuntooyinka waxay leeyihiin khusayn gaar ah;waxay ku xasilan tahay asiidhyada iyo alkaliska, laakiin haddii qiimaha PH uu dhaafo 2 ~ 11 oo ay saamayso heerkulka sare ama uu leeyahay waqti kaydinta dheer, viscosity ayaa hoos u dhacaya;xalkeeda aqueous waxay bixin kartaa dhaqdhaqaaqa dusha sare, oo muujinaya xiisadda dusha dhexdhexaadka ah iyo qiyamka xiisadda wejiyada;waxay leedahay emulsification wax ku ool ah oo ku jira nidaamyada laba-weji, waxaa loo isticmaali karaa xasiliye wax ku ool ah iyo kolloid ilaalin ah;xalkeeda aqueous waxay leedahay sifooyin filim samaynta heer sare ah, waana kaniiniga iyo kaniiniga Wax daahan wanaagsan.Dahaarka filimka ee ay samaysay waxay leedahay faa'iidooyinka midab la'aanta iyo adkaanta.Ku darida glycerin waxay sidoo kale wanaajin kartaa caagnimada.
Baakadaha
Tbaakadaha caadiga ah waa 25kg/Fiberdurbaan
20'FCL: 9 tan oo leh palletized;10 tan oo aan miir lahayn.
40'FCL:18tan oo leh palletized;20tan aan palette lahayn.
Kaydinta:
Ku kaydi meel qabow oo qallalan oo ka hooseysa 30 ° C oo laga ilaaliyo qoyaanka iyo cadaadiska, maadaama alaabtu tahay heerkulbeeg, wakhtiga kaydinta waa inuusan ka badan 36 bilood.
Qoraallada badbaadada:
Xogta kor ku xusan waxay waafaqsan tahay aqoontayada, laakiin ha ka nadiifin macaamiisha si taxadar leh u hubiya dhammaan isla markiiba marka la helo.Si aad isaga ilaaliso diyaarinta kala duwan iyo alaabta ceeriin ee kala duwan, fadlan samee baaritaan dheeraad ah ka hor intaadan isticmaalin.
Waqtiga boostada: Jan-01-2024