Hydroxypropylmethylcellulose (HPMC) waa polymer isku dhafan oo si ballaaran loogu isticmaalo warshado kala duwan sababo la xiriira sifooyinka gaarka ah. Xaruntani waa unug ka soo jeeda cellulose, polymer-ka dabiiciga ah ee laga helo gidaarada unugyada dhirta. Isku-dubaridka HPMC waxay ku lug leedahay daaweynta cellulose leh propylene oxide si loo soo bandhigo kooxaha hydroxypropyl iyo methyl chloride si loo soo bandhigo kooxaha methyl. Polymer-ka soo baxay waxa uu soo bandhigayaa waxyaabo badan oo jidheed iyo kiimiko ah, taas oo ka dhigaysa mid ku habboon in loo isticmaalo dawooyinka, dhismaha, cuntada iyo warshadaha kale.
1.Qaabka kiimikaad iyo halabuurka:
Hydroxypropyl methylcellulose waa polymer semi-synthetic ah oo leh qaab-dhismeedka kiimikada adag. Laf-dhabarka polymer-ka wuxuu ka kooban yahay cellulose, silsilad toosan oo gulukoos unugyo ah oo ku xiran β-1,4-glycosidic bonds. Kooxda hydroxypropyl waxaa lagu soo bandhigay iyadoo lagu bedelayo kooxda hydroxyl (-OH) koox propyl ah, kooxda methylna waxaa loo soo bandhigay si la mid ah. Darajada beddelka (DS) waxay ka dhigan tahay celceliska tirada hydroxypropyl iyo methyl koox kasta oo gulukoos waxayna saamaysaa milanka, viscosity, iyo guryaha kulaylka ee polymerka.
2. Soluble:
Mid ka mid ah sifooyinka gaarka ah ee HPMC waa habdhaqankeeda kala diris. Waxay ku milmi kartaa labadaba qabow iyo biyo kulul, iyagoo bixiya faa'iidooyin gaar ah oo ku saabsan codsiyada kala duwan. Solubility waxaa lagu hagaajin karaa iyadoo la hagaajinayo heerka beddelka iyo miisaanka kelli ee polymerka. Hantidan ayaa ka dhigaysa HPMC musharrax heersare ah oo loogu talagalay nidaamyada gudbinta maandooriyaha ee la xakameeyey, halkaas oo heerka kala diridu uu door muhiim ah ka ciyaaro kinetics-ka daroogada.
3. Viscosity:
Hydroxypropyl methylcellulose waxaa lagu heli karaa noocyo kala duwan oo heerar viscosity ah, taas oo ku xidhan arrimo ay ka mid yihiin miisaanka kelli, heerka beddelka, iyo xoojinta xalka. Viscosity ee xal HPMC iyaga u ogolaanaya in loo isticmaalo in codsiyada badan oo warshadaha, oo ay ku jiraan dawooyinka, sida dhumucyada ee foomamka qiyaasta dareere ah, iyo sida filimada-samaynta alaabta ee daahan.
4. Bandhiga samaynta filimada:
Awoodda samaynta filimada ee HPMC waxay muhiim u tahay codsiyada sida dahaarka daroogada, halkaas oo loo isticmaalo in lagu bixiyo lakab ilaalin si loo daboolo dhadhanka daroogada, loo xakameeyo sii deynta daroogada, iyo hagaajinta xasilloonida. Filimada HPMC waa kuwo cad oo dabacsan, hantidoodana waxaa lagu habeyn karaa iyadoo la hagaajinayo fiirsashada polymer, miisaanka molecular iyo waxyaabaha ku jira balaastiga.
5. Waxqabadka kulaylka:
Hydroxypropyl methylcellulose waxa ay muujisaa degganaansho kulayl oo wanaagsan gudaha heerkul gaar ah. Guryaha kulaylka waxaa saameeya arrimo ay ka mid yihiin heerka beddelka, miisaanka unugyada, iyo joogitaanka balaastikada. Guryahaani waxay HPMC ka dhigayaan mid ku haboon codsiyada halka xasiloonida kulaylku ay muhiim tahay, sida diyaarinta daawooyinka kulaylka xasaasiga ah.
6. Waafaqid noole:
Goobaha dawooyinka iyo cilmiga noolaha, biocompatibility waa tixgalin muhiim ah oo loogu talagalay agabka loo isticmaalo hababka gudbinta daroogada. Hydroxypropyl methylcellulose guud ahaan waxaa loo arkaa badbaado waxayna leedahay noole ku habboonaansho wanaagsan. Waxaa si weyn loogu isticmaalaa samaynta foomamka qiyaasta qiyaasta afka, xalalka indhaha iyo hababka gudbinta daawada la xakameeyey.
7. Haysashada biyaha iyo guryaha dhumucda:
Awoodda HPMC ee ay ku hayso biyaha iyo dhumucda xalalka waxay ka dhigaysaa mid qiimo leh qalabka dhismaha sida alaabta sibidhka ku salaysan. Codsiyadan, HPMC waxay u shaqeysaa sidii wakiilka biyaha celiya, wanaajinta habsocodka iyo ka hortagga qallajinta alaabta. Guryaha dhumucda ayaa sidoo kale loo isticmaalaa noocyo kala duwan oo cunto ah si kor loogu qaado dhadhanka iyo dareenka afka.
8. Soo-dejinta daawada la xakameeyey:
Mid ka mid ah codsiyada muhiimka ah ee hydroxypropyl methylcellulose ayaa ku jira samaynta hababka gudbinta daroogada ee la xakameeyey. milanka polymerka, viscosity, iyo guryaha samaynta filimku waxa ay fududeeyaan sii daynta daawada la xakameeyey, taas oo awood u siinaysa bixinta daawada joogtada ah iyo bartilmaameedka. Tani waxay si gaar ah faa'iido u leedahay hagaajinta u hoggaansanaanta bukaan-socodka iyo yaraynta dhibaatooyinka soo raaca ee la xiriira sii-deynta daawada degdegga ah.
9. Xasilooni hoos yimaada bey'ada pH ee kala duwan:
HPMC waxa ay muujisaa xasilooni balaadhan oo pH ah, taas oo ka dhigaysa mid ku haboon qaabaynta u baahan xasilooni hoos yimaada xaaladaha acidic ama alkaline. Hantidan ayaa faa'iido u leh dawooyinka sababtoo ah qaababka daroogada ayaa laga yaabaa inay la kulmaan bey'ado kala duwan oo pH ah ee mareenka caloosha iyo mindhicirka.
10. sifooyinka Rheological:
Dabeecadda rheological ee xalalka HPMC ayaa muhiim u ah codsiyada halka ay sifooyinka socodka ay muhiim u yihiin, sida diyaarinta dahaarka, xabagta iyo jelka. Sifooyinka rheological waxaa lagu habeyn karaa iyadoo la hagaajinayo diiradda iyo culeyska kelli ee HPMC si loo gaaro sifooyinka socodka ee looga baahan yahay xakamaynta elektaroonigga ah ee saxda ah.
Hydroxypropyl methylcellulose waxay noqotay polymer lagama maarmaanka u ah warshado kala duwan iyadoo ay ugu wacan tahay isku dhafka gaarka ah ee milanka, viscosity, kartida samaynta filimada iyo biocompatibility. Kala duwanaanshaheeda ayaa ka dhigaya mid ku habboon codsiyada kala duwan, laga bilaabo dawooyinka iyo qalabka dhismaha ilaa cuntada iyo qurxinta. Sida cilmi-baarayaashu ay sii wadaan sahaminta hababka cusub iyo codsiyada, sifooyinka hydroxypropyl methylcellulose shaki la'aan waxay gacan ka geysan doonaan horumarinta qaybaha kala duwan, hubinta muhiimada sii socota ee sayniska iyo warshadaha.
Waqtiga boostada: Jan-10-2024