Hydroxypropyl Methyl Cellulose (HPMC), oo sidoo kale loo yaqaano magaca ganacsiga hypromellose, waa polymer synthetic ah oo laga soo qaatay cellulose dabiiciga ah. Isha ugu muhiimsan ee cellulose ee wax soo saarka HPMC waa caadi ahaan saxarka alwaax ama suuf. Habka wax-soo-saarku waxa uu ku lug leeyahay in si kiimiko ah wax looga beddelo cellulose-ka iyada oo loo marayo etherification, soo bandhigida kooxaha hydroxypropyl iyo methyl ee lafta dhabarka cellulose.

Soo saarista HPMC waxay ku lug leedahay dhowr tillaabo:

1. Soo saarista Cellulose:
   • Cellulose waxaa laga helaa ilaha dhirta, ugu horrayn saxarka alwaax ama suuf. Cellulose waa la soo saaray oo la nadiifiyaa si ay u sameeyaan saxarka cellulose.
2. Alkalisation:
   • Saxarka cellulose waxaa lagu daaweeyaa xal alkaline ah, badiyaa sodium hydroxide (NaOH), si loo dhaqaajiyo kooxaha hydroxyl ee silsiladda cellulose.
3. Etherification:
   • Etherification waa tallaabada ugu muhiimsan ee wax soo saarka HPMC. Cellulose-ka alkalized waxaa lagu falceliyaa propylene oxide (kooxaha hydroxypropyl) iyo methyl chloride (kooxaha methyl) si loogu soo bandhigo kooxahan ether-ka lafta dhabarka cellulose.
4. Dhexdhexaadinta iyo Dhaqidda:
   • Natiijadii ka soo baxday cellulose ee la beddelay, oo hadda ah Hydroxypropyl Methyl Cellulose, waxay maraysaa hab dhexdhexaad ah si looga saaro wax kasta oo alkali ah. Kadibna si fiican ayaa loo dhaqaa si loo tirtiro wasakhda iyo alaabta ka soo baxda.
5. Qalajinta iyo milanka:
   • Cellulose-ka wax laga beddelay waa la qalajiyey si looga saaro qoyaanka xad-dhaafka ah ka dibna waxaa lagu shiiday budo fiican. Cabbirka walxaha waxaa lagu xakameyn karaa iyadoo lagu saleynayo codsiga loogu talagalay.

Badeecada HPMC ee ka soo baxday waa budo cad ama ka baxsan oo leh heerar kala duwan oo ah hydroxypropyl iyo beddelka methyl. Sifooyinka gaarka ah ee HPMC, sida milmaheeda, viscosity, iyo sifooyinka waxqabad ee kale, waxay ku xidhan yihiin heerka beddelka iyo habka wax soo saarka.

Waxaa muhiim ah in la ogaado in HPMC uu yahay polymer semi-synthetic ah, iyo in kasta oo laga soo qaatay cellulose dabiiciga ah, waxay maraysaa isbeddello kiimiko ah oo muhiim ah inta lagu jiro habka wax soo saarka si loo gaaro sifooyinka la rabo ee codsiyada warshadaha kala duwan.